How-To queries answer fundamental data analysis questions of the form: "How should the input change in order to achieve the desired output". As a Reverse Data Management problem, the evaluation of how-to queries is harder than their "forward" counterpart: hypothetical, or what-if queries.
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Meliou et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: