Vascular abnormalities in scleroderma

Vascular abnormalities represent a fundamental event in the pathogenesis of systemic sclerosis. This review focuses on key observations that support this view and builds a framework with which to clarify our understanding of how endothelial cell damage may trigger a self-fueling process ending in pathological tissue fibrosis in those susceptible to scleroderma. The studies reviewed in this article pertain to systemic sclerosis patients.