Key result
ACE underexpression in heterozygous knockout mice did not prevent cardiac hypertrophy (LV weight/body weight ratio increased 74% vs sham) or LV dysfunction in response to volume overload.
Why the study?
Does genetic variation in ACE affect the development of cardiac hypertrophy and LV dysfunction in response to volume overload in mice?
Population
Male heterozygous ACE knockout (1/0) and wild-type (1/1) mice
Comparison
Creation of an aortocaval fistula to induce… vs Sham-operated control mice
Design
Preclinical
Follow-up
4 weeks
Authors
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Does not support ACE targeting to prevent volume-overload hypertrophy; leaves open ACE-independent pathways in human remodeling.
Does genetic variation in ACE affect the development of cardiac hypertrophy and LV dysfunction in response to volume overload in mice?
ACE underexpression does not prevent cardiac hypertrophy or LV dysfunction in response to volume overload in mice, as the heart maintains angiotensin II levels despite genetic ACE variation.
Perry et al. (2001) studied Cardiac hypertrophy and volume overload. Heterozygous ACE knockout (1/0) genotype vs. Wild-type (1/1) genotype was evaluated on Development of cardiac hypertrophy (LV weight/body weight ratio) and LV dysfunction. ACE underexpression in heterozygous knockout mice did not prevent cardiac hypertrophy (LV weight/body weight ratio increased 74% vs sham) or LV dysfunction in response to volume overload.
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