Key result
Multiple subcortical lacunar infarcts were associated with significant deficits in executive function and frontal system dysfunction, even though only 27% met the criteria for clinical dementia.
Why the study?
Do multiple subcortical lacunar infarcts cause frontal systems impairment compared to healthy controls?
Population
22 subjects: 11 with multiple subcortical lacunar infarcts and 11 medical control subjects matched for age…
Comparison
Multiple subcortical lacunar infarcts (exposure) vs Medical control subjects matched for age and…
Design
Case-control
Authors
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May warrant broader cognitive screening beyond dementia in lacunar infarcts; leaves open causal mechanisms and need for prospective studies.
Case-Control (n=22)
Do multiple subcortical lacunar infarcts cause frontal systems impairment compared to healthy controls?
Multiple subcortical lacunar infarcts are associated with a continuum of cognitive impairments, particularly frontal systems dysfunction, even in the absence of overt dementia.
Wolfe et al. (1990) conducted a case-control in Multiple subcortical lacunar infarcts (n=22). Multiple subcortical lacunar infarcts vs. Medical control subjects with no central nervous system disease was evaluated on Neuropsychological performance (frontal system dysfunction, shifting mental set, response inhibition, executive function). Multiple subcortical lacunar infarcts were associated with significant deficits in executive function and frontal system dysfunction, even though only 27% met the criteria for clinical dementia.
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