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Indomethacin at a concentration (10(-4) M) which depressed the effect on O2- generation by fMet-Leu-Phe, markedly enhanced O-2 generation by both 1-oleoyl-2-acetylglycerol and the calcium ionophore, A23187. These results are explicable in terms of the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil.
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Dale et al. (1985) studied this question.
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