Key points are not available for this paper at this time.
Significance Air pollution is a major public health concern worldwide. The molecular mechanistic underpinnings of the health effects of air pollution are not fully understood, and the lack of individual-level preventative options represent a critical knowledge gap. Our study demonstrated the epigenetic effects of air pollution and suggested that B vitamins might be used as prevention to complement regulations to attenuate the impact of air pollution on the epigenome. Our study inaugurated a line of research for the development of preventive interventions to minimize the adverse effects of air pollution on potential mechanistic markers. Because of the central role of epigenetic modifications in mediating environmental effects, our findings might be extended to other toxicants and environmental diseases.
Zhong et al. (2017) studied this question.