Key result
In a 2D computational model, increasing mitral regurgitation severity from mild to severe decreased intraventricular pressure to 0.9 kPa and increased regurgitant jet velocity up to 6 m/s.
Why the study?
The study was conducted to simulate mitral regurgitation disease progression from mild to severe intensity using a fluid-structure interaction model.
A 2D fluid-structure interaction model successfully simulated the hemodynamic and biomechanical effects of mitral regurgitation progression, demonstrating the impact of leaflet separation on regurgitant flow.
Computational models can simulate mitral regurgitation hemodynamics; leaves open clinical translation pending 3D and patient validation.
The aim of this study is to simulate the Mitral Regurgitation (MR) disease progression from mild to severe intensity. A Fluid Structure Interaction (FSI) model was developed to extract the hemodynamic parameters of blood flow in mitral regurgitation (MR) during systole. A two-dimensional (2D) geometry of the mitral valve was built based on the data resulting from Magnetic Resonance Imaging (MRI) dimensional measurements. The leaflets were assumed to be elastic. Using COMSOL software, the hemodynamic parameters of blood flow including velocity, pressure, and Von Mises stress contours were obtained by moving arbitrary Lagrange-Euler mesh. The results were obtained for normal and MR cases. They showed the effects of the abnormal distance between the leaflets on the amount of returned flow. Furthermore, the deformation of the leaflets was measured during systole. The results were found to be consistent with the relevant literature.
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Esfahani et al. (2018) studied Mitral Regurgitation. Mitral regurgitation severity (mild, moderate, severe gap sizes) vs. Normal/healthy valve or mild MR was evaluated on Hemodynamic parameters (pressure, velocity, Von Mises stress). In a 2D computational model, increasing mitral regurgitation severity from mild to severe decreased intraventricular pressure to 0.9 kPa and increased regurgitant jet velocity up to 6 m/s.
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