Key result
Multiple sclerosis is a complex genetic disease associated with CNS inflammation mediated by autoreactive T cells, with emerging therapies targeting these immune pathways.
High-throughput examination of germline DNA haplotypes, RNA expression, and protein structures may allow the generation of new hypotheses to develop better understanding and therapies for multiple sclerosis.
Does not alter MS management; leaves open whether high-throughput haplotype analyses will yield new therapies.
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
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David A. Hafler (2004) conducted a review in Multiple sclerosis. Multiple sclerosis is a complex genetic disease associated with CNS inflammation mediated by autoreactive T cells, with emerging therapies targeting these immune pathways.
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