March 15, 2004Open Access
Multiple sclerosis
Key Result
Multiple sclerosis is a complex genetic disease associated with CNS inflammation mediated by autoreactive T cells, with emerging therapies targeting these immune pathways.
Structured PICO
P
Population
Patients with multiple sclerosis
High-throughput examination of germline DNA haplotypes, RNA expression, and protein structures may allow the generation of new hypotheses to develop better understanding and therapies for multiple sclerosis.
Abstract
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.