Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

In vitro AT1R-overexpressing cells exposed to osmotic stretch, and in vivo mouse models including mice undergoing cardiac pressure overload, mice with global and cardiomyocyte conditional deletion of β-arrestin2, and AT1R knockout mice.

Cardiac pressure overload (in vivo) and osmotic stretch (in vitro); exogenous administration of AT1R-enriched exosomes.

Secretion and activity of exosomes containing AT1R, and blood pressure responsiveness to angiotensin II infusion.surrogate