Key result
A 30-minute hypoxic test induced significant elevations (p<0.05) in pulmonary artery pressures, right atrial and ventricular pressures, and cardiac index in patients with PSS and PAH.
Why the study?
Does the hypoxic test affect left and right ventricular contractility in patients with progressive systemic sclerosis and pulmonary arterial hypertension?
Observational (n=10)
Does the hypoxic test affect left and right ventricular contractility in patients with progressive systemic sclerosis and pulmonary arterial hypertension?
In patients with progressive systemic sclerosis and pulmonary arterial hypertension, hypoxia induces pulmonary artery hyperreactivity while preserving compensatory right and left ventricular contractility.
Answers are grounded in this paper and cite their sources.
Hypoxia may preserve ventricular contractility despite pressure rises in PSS-PAH; hypothesis-generating for prognostic testing.
The purpose of this investigation was to assess hypoxic test effects on left and right ventricular contractility in patients with progressive systemic sclerosis (PSS) and pulmonary arterial hypertension (PAH). Ten patients (mean age 48.8 ± 13.2 years) who were diagnosed with PSS and PAH were included in the study. All the patients underwent left and right heart catheterization. Right ventricular (RV) contractility was measured according to the method of Ferlinz [1] and left ventricular (LV) contractility according to the method of Kennedy et al. [2] using indirect digital substraction angiography. The mean pulmonary artery pressures (PPA) and oxygen saturation of the pulmonary artery (SaO2) were registered at each stage of graded hypoxic exposure 14%, 12%, and 10% of O2. Right atrial pressures (PRA,syst, PRA,diast,PRA), right ventricular pressures (PRV,syst, PRV,diast,PRV, PRV,end-diast), right and left ventricular end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), cardiac index (CI), ejection fraction (EF), and heart rate (HR) were calculated before and after breathing a hypoxic mixture of 10% of O2 for 30 minutes. The hypoxic test induced significant elevation (p <0.05) of PPA, PRA,syst, PRA,diast,PRA, PRV,syst, PRV,end-diast, RV EDVI, LV, EDVI, CI, and HR, whereas, SaO2 decreased significantly after the hypoxic test. These findings suggest that patients with PSS and PAH are characterized by hyperreactivity of pulmonary artery to hypoxia and the preservation of compensatory mechanism of RV and LV contractility.
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Ta et al. (2005) conducted an observational in Progressive systemic sclerosis (PSS) and pulmonary arterial hypertension (PAH) (n=10). Hypoxic test (10% O2 mixture) vs. Baseline (before hypoxic exposure) was evaluated on Left and right ventricular contractility and hemodynamics (including PPA, PRA, PRV, EDVI, CI, HR, and SaO2) (p=<0.05). A 30-minute hypoxic test induced significant elevations (p<0.05) in pulmonary artery pressures, right atrial and ventricular pressures, and cardiac index in patients with PSS and PAH.
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