Why the study?
Recent evidence suggests a link between lean body mass and cardiovascular capacity in women, prompting investigation into sex-specific relationships with central and peripheral circulatory variables.
Does lean body mass associate with central and peripheral circulatory variables differently in healthy women compared to men?
Cross-Sectional (n=70)
Does lean body mass associate with central and peripheral circulatory variables differently in healthy women compared to men?
Effect estimate: r ≥0.53
p-value: p=≤0.002
Lean body mass independently associates with internal cardiac dimensions, ventricular relaxation, and systemic vascular resistance exclusively in women, highlighting a sex-specific cardiovascular physiological relationship.
Recent evidence points toward a link between lean body mass (LBM) and cardiovascular capacity in women. This study aimed at determining the sex-specific relationship of LBM with central and peripheral circulatory variables in healthy women and men ( n =70) matched by age (60±12 years versus 58±15 years), physical activity, and cardiovascular risk factors. Regional (legs, arms, and trunk) and whole-body (total) body composition were assessed via dual-energy x-ray absorptiometry. Cardiac structure, function, and central/peripheral hemodynamics were measured via transthoracic echocardiography and the volume-clamp method at rest and peak incremental exercise. Regression analyses determined sex-specific relationships between LBM and cardiovascular variables. Regional and total LBM were lower in women than men ( P <0.001), with little overlap between sexes. Leg and arm LBM positively associated with left ventricular (LV) internal resting dimensions in women ( r ≥0.53, P ≤0.002) but not men ( P ≥0.156). Leg, arm, and total LBM only associated with LV relaxation in women ( r ≥0.43, P ≤0.013). All LBM variables strongly associated with LV volumes at peak exercise in women ( r ≥0.54, P ≤0.001) but not men and negatively associated with total peripheral resistance at peak exercise in women ( r ≥0.43, P ≤0.023). Adjustment by adiposity-related or cardiovascular risk factors did not alter results. In conclusion, leg and arm LBM independently associate with internal cardiac dimensions, ventricular relaxation, and systemic vascular resistance in a sex-specific manner, with these relationships exclusively present in women.
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Díaz-Cañestro et al. (2022) conducted a cross-sectional in Healthy (n=70). Lean body mass (LBM) vs. Men (sex comparison) was evaluated on Left ventricular internal resting dimensions (r ≥0.53, p=≤0.002).
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