Key result
Symptoms of depression and anxiety were more prevalent in people with mild cognitive impairment than in those with normal cognitive function, and increased the risk of progression to MCI.
Why the study?
Do symptoms of depression and anxiety increase the risk of progression to mild cognitive impairment and dementia?
Systematic Review
Do symptoms of depression and anxiety increase the risk of progression to mild cognitive impairment and dementia?
Symptoms of depression and anxiety are more prevalent in MCI and increase the risk of progression from normal cognition to MCI.
Summary This systematic review, with meta-analyses conducted where data were available, aimed to investigate the prevalence of symptoms of depression and anxiety in mild cognitive impairment (MCI), and to establish how symptoms of depression and anxiety relate to the progression from no cognitive impairment to MCI, and from MCI to dementia. Sixty studies were included in the review. Meta-analyses indicated that symptoms of depression and anxiety were more prevalent in people with MCI than in people with normal cognitive function, and increased the risk of progression from no cognitive impairment to MCI. There were mixed results regarding the effect of such symptoms on progression from MCI to dementia. The findings highlight the need for more research in this area, which can inform attempts to slow or halt the progression of cognitive impairment in later life, with resulting benefits for quality of life.
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Yates et al. (2013) conducted a systematic review in Mild cognitive impairment. Symptoms of depression and anxiety vs. Normal cognitive function / absence of symptoms was evaluated on Prevalence of depression and anxiety in MCI and progression to MCI or dementia. Symptoms of depression and anxiety were more prevalent in people with mild cognitive impairment than in those with normal cognitive function, and increased the risk of progression to MCI.
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