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May 1, 1991Journal of Biological ChemistryOpen Access

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

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Authors

Kristian HelinKristian HelinGoethe University FrankfurtLBLaura BeguinotUniversity of Copenhagen

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Helin et al. (1991) studied this question.

synapsesocial.com/papers/6a202f06ca1e0a8823d8d644https://doi.org/10.1016/s0021-9258(18)92984-4
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Also Consider

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  1. 1Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.1979 · 530 citations
  2. 2Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.1980 · 453 citations
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  4. 4Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor.1988 · 76 citations
  5. 5Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.1985 · 199 citations