Basal inferior longitudinal strain was significantly lower in patients with ATTR-CM compared to non-amyloid cardiomyopathy (4.6 vs 10.7, P<0.01) and demonstrated high diagnostic utility with an AUC of 0.86.
Cohort (n=66)
No
Does regional longitudinal strain (specifically basal inferior LS) identify transthyretin amyloid cardiomyopathy in elderly patients?
Basal inferior longitudinal strain measured by 2D speckle-tracking echocardiography is a useful diagnostic marker for identifying transthyretin amyloid cardiomyopathy.
Effect estimate: AUC 0.86
Absolute Event Rate: 4.6% vs 10.7%
p-value: p=<0.01
Background: Evaluation of the utility of regional longitudinal strain (LS) to identify transthyretin amyloid cardiomyopathy (ATTR-CM). Methods and Results: Tc-labeled pyrophosphate scintigraphy and had enough information for 2-dimensional speckle-tracking echocardiography. Patients were divided into ATTR-CM group (n=37) and non-amyloid cardiomyopathy group (n=29). Basal inferior LS was significantly lower in the ATTR-CM group than in the non-amyloid cardiomyopathy group (4.6±3.9 vs. 10.7±5.4, P<0.01). ROC analysis showed that the basal inferior LS value was useful for identifying ATTR-CM (area under curve: 0.86). Conclusions: Basal inferior LS value is the most useful for identifying ATTR-CM.
Usuku et al. (Mon,) conducted a cohort in Transthyretin amyloid cardiomyopathy (n=66). Basal inferior longitudinal strain vs. Non-amyloid cardiomyopathy was evaluated on Basal inferior longitudinal strain (LS) to identify ATTR-CM (AUC 0.86, p=<0.01). Basal inferior longitudinal strain was significantly lower in patients with ATTR-CM compared to non-amyloid cardiomyopathy (4.6 vs 10.7, P<0.01) and demonstrated high diagnostic utility with an AUC of 0.86.