Key result
Lower basal inferior longitudinal strain distinguishes ATTR-CM from non-amyloid cardiomyopathy with an AUC of 0.86.
Why the study?
The study evaluated the utility of regional longitudinal strain to identify transthyretin amyloid cardiomyopathy.
Does regional longitudinal strain (specifically basal inferior LS) identify transthyretin amyloid cardiomyopathy in elderly patients?
Cohort (n=66)
No
Does regional longitudinal strain (specifically basal inferior LS) identify transthyretin amyloid cardiomyopathy in elderly patients?
Effect estimate: AUC 0.86
Absolute Event Rate: 4.6% vs 10.7%
p-value: p=<0.01
Basal inferior longitudinal strain measured by 2D speckle-tracking echocardiography is a useful diagnostic marker for identifying transthyretin amyloid cardiomyopathy.
Background: Evaluation of the utility of regional longitudinal strain (LS) to identify transthyretin amyloid cardiomyopathy (ATTR-CM). Methods and Results: Tc-labeled pyrophosphate scintigraphy and had enough information for 2-dimensional speckle-tracking echocardiography. Patients were divided into ATTR-CM group (n=37) and non-amyloid cardiomyopathy group (n=29). Basal inferior LS was significantly lower in the ATTR-CM group than in the non-amyloid cardiomyopathy group (4.6±3.9 vs. 10.7±5.4, P<0.01). ROC analysis showed that the basal inferior LS value was useful for identifying ATTR-CM (area under curve: 0.86). Conclusions: Basal inferior LS value is the most useful for identifying ATTR-CM.
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Usuku et al. (2025) conducted a cohort in Transthyretin amyloid cardiomyopathy (n=66). Basal inferior longitudinal strain vs. Non-amyloid cardiomyopathy was evaluated on Basal inferior longitudinal strain (LS) to identify ATTR-CM (AUC 0.86, p=<0.01). Basal inferior longitudinal strain was significantly lower in patients with ATTR-CM compared to non-amyloid cardiomyopathy (4.6 vs 10.7, P<0.01) and demonstrated high diagnostic utility with an AUC of 0.86.
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