Computational phantom for red bone marrow dosimetry in adult males and females

In t roduc t ion. The dose assessment of internal irradiation of red bone marrow (RBM) by osteotropic radionuclides is based on dosimetric modeling using computational phantoms. Creating such phantoms for 89.90Sr requires careful description of the shape and size of bones, as well as their microarchitecture. Descriptions of phantoms representing newborn, one-year-old, 5-year-old, and 10-year-old children have been published. Our study continues work on creating a set of computational skeletal phantoms for people of different ages. O bject iv e . Development of computational skeletal phantoms of male and female adults for estimating radiation doses of beta-emitting radionuclides incorporated in RBM. Mate rials a nd met hods. The stochastic parametric skeletal dosimetry (SPSD) method of creating phantoms was used. The skeletal sections with active hematopoiesis were divided into segments. On the basis of literature data, the parameters of segment models were evaluated: linear dimensions, cortical layer thickness, bone microarchitecture characteristics, density, chemical composition, and RBM proportion. Resul t s. The developed phantoms of male and female adults are composite, including 46 segments each; the parameters of 21 segments were independent of sex. The sizes of segment phantoms range within 4–66 mm; the cortical layer thickness ranges within 0.3–2.2 mm. The parameters of bone segment microarchitecture are presented. C onclusions. The resulting phantoms simulate the microand macro-architecture of bone tissue, and, together with sets of additional phantoms, represent the population variability of individual skeletal bones and take sex differences into account. The developed phantoms can be used for internal dosimetry of osteotropic beta-emitters, including as part of radiopharmaceuticals.