Attitudes, Motivation, and Predictors of Influenza Vaccination Uptake Among Primary Healthcare Professionals in Greece

Background: Influenza vaccination uptake among healthcare professionals remains suboptimal despite their key role in influencing public vaccination behavior. This study investigated motivational and behavioral determinants of influenza vaccination uptake and advocacy among primary healthcare professionals in Greece. Methods: A cross-sectional study was conducted among 304 physicians and pharmacists using an anonymous online questionnaire. Vaccination uptake (2023–2024 season and annual) and motivational and advocacy constructs were assessed using the validated MoVac-flu and MovAd scales. Factor structure was evaluated using confirmatory and exploratory factor analyses. Multivariable logistic regression models were applied to identify predictors of vaccination uptake. Results: The study sample consisted of 304 healthcare professionals of whom 61.2% were physicians and 38.8% were pharmacists. More than half of the participants were female (52.6%) and aged 41–60 years (57.6%). Influenza vaccination uptake was 77.6% for the 2023–2024 season and 75.3% for annual vaccination. A two-factor structure was identified for the MoVac-flu scale (F1: Vax Self-Care, F2: Vax Awareness), whereas a four-factor structure was identified for the MovAd scale (F1: Vax Communication, F2: Vax Influence, F3: Vax Confidence, F4: Vax Choice). The overall scales demonstrated high internal consistency, while most subscales showed satisfactory to high reliability. Motivation toward influenza vaccination and vaccination advocacy were high among the participants. Vaccinated participants demonstrated higher motivation and vaccination advocacy scores compared with non-vaccinated participants. In multivariable analyses, higher scores on Vax Self-Care (aOR = 3.22, 95% CI: 2.08–4.96, p < 0.001) and Vax Communication (aOR = 1.64, 95% CI: 1.14–2.34, p = 0.007) subscales, reflecting higher motivation and vaccination advocacy, respectively, as well as male sex (aOR = 2.35, 95% CI: 1.14–4.83, p = 0.020) were associated with higher odds of annual vaccination. Higher scores on the Vax Self-Care subscale (aOR = 3.66, 95% CI: 2.33–5.77, p < 0.001) were also found to be associated with higher odds of 2023–2024 vaccination uptake, as well as living with vulnerable individuals (aOR = 2.95, 95% CI: 1.18–7.38, p = 0.020). Conclusions: Influenza vaccination uptake among primary healthcare professionals in Greece was relatively high; however, it was strongly driven by intrinsic motivational factors, particularly the perceived personal and public health benefits of vaccination. Communication-related competencies also independently contributed to vaccination behavior, highlighting the link between professional practice and personal uptake. In contrast, household-related contextual characteristics, such as cohabitation with vulnerable individuals, appeared to exert a less consistent influence on vaccination behavior. These findings suggest that interventions focusing on strengthening intrinsic motivation and communication skills may contribute to sustained improvements in both vaccination uptake and advocacy among healthcare professionals.