Key result
Delayed verbal memory and hippocampal volume best discriminated MCI from controls among 45 subjects, whereas P300 amplitude was reduced in Alzheimer's dementia but not MCI.
Why the study?
Does the P300 event-related brain potential, delayed verbal memory, or hippocampal volume distinguish between patients with DAT, MCI, and normal controls?
Cross-Sectional (n=45)
Does the P300 event-related brain potential, delayed verbal memory, or hippocampal volume distinguish between patients with DAT, MCI, and normal controls?
Neuropsychological and neuroanatomical measures are useful in diagnosing dementia and MCI, whereas P300 amplitude is not sensitive to mild memory dysfunction.
Memory testing and hippocampal volumetry may aid MCI identification; leaves open P300 utility in prodromal stages.
We investigated the sensitivity of the P300 event-related brain potential (ERP) recorded during a memory-demanding task to memory function in subjects with dementia of the Alzheimer's type (DAT), those with mild cognitive impairment (MCI), and normal elderly controls. We also explored the ability of neuropsychological (delayed verbal memory), neuroanatomical (MRI-based hippocampal volume), and electrophysiological (memory search P300 amplitude) memory measures to distinguish between the three subject groups using discriminant function analyses. Fourteen patients with DAT, 16 with MCI, and 15 age- and education-matched controls were tested. P300 amplitude was reduced in DAT subjects at all levels of memory load; however, it did not differ between MCI and control subjects. Delayed verbal memory performance best discriminated DAT from MCI and control subjects, while delayed verbal memory and hippocampal volume best discriminated MCI subjects from controls. These results support the utility of neuropsychological and neuroanatomical measures in diagnosing dementia and do not support the notion that P300 amplitude is sensitive to mild memory dysfunction when measured using the current task.
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Phillips et al. (2004) conducted a cross-sectional in Alzheimer's disease and mild cognitive impairment (n=45). Neuropsychological, neuroanatomical, and electrophysiological memory measures vs. Normal elderly controls was evaluated on Ability to distinguish between DAT, MCI, and control groups. Delayed verbal memory and hippocampal volume best discriminated MCI from controls among 45 subjects, whereas P300 amplitude was reduced in Alzheimer's dementia but not MCI.
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