Key result
Screening of a family with Brugada syndrome identified the SCN5A R367H mutation, while ajmaline administration produced false-positive ECG results in two individuals without the mutation.
Observational
The study identifies the SCN5A R367H mutation in a European family with Brugada syndrome, suggesting it shares pathophysiology with sudden unexpected death syndrome and highlighting that ajmaline challenge may yield false-positive ECG results.
No takes yet. Share an insight, caveat, or question.
Raises caution for ajmaline false positives in Brugada family screening; leaves open SCN5A R367H role in sudden death syndromes.
Hong et al. (2004) conducted an observational in Brugada syndrome. SCN5A R367H mutation was evaluated on Presence of SCN5A mutation and Brugada ECG pattern. Screening of a family with Brugada syndrome identified the SCN5A R367H mutation, while ajmaline administration produced false-positive ECG results in two individuals without the mutation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: