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November 19, 2014Chemical Science153 citationsOpen Access

Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition

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SMSiddharth S. MatikondaDODouglas L. OrsiVSVerena Staudacher

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Abstract

-cyclooctenol (CCO-OH) no activation was observed. The data also demonstrates the potential of this reaction in organic synthesis as a mild orthogonal protecting group strategy for amino and hydroxyl groups.

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Matikonda et al. (2014) studied this question.

synapsesocial.com/papers/6a203b400a9d8fc05fd8e6f2https://doi.org/10.1039/c4sc02574a
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