Why the study?
What are the clinical and electrocardiographic predictors of significant left main coronary artery disease in high-risk patients with a first episode of NSTE-ACS?
Observational (n=100)
No
What are the clinical and electrocardiographic predictors of significant left main coronary artery disease in high-risk patients with a first episode of NSTE-ACS?
In high-risk Indian patients with a first episode of NSTE-ACS, central obesity, signs of left heart failure, and ST elevation in aVR are strong clinical predictors of significant left main coronary artery disease.
Ischaemic heart disease is the leading cause of death globally. In 2001, ischaemic heart disease accounted for 71 million deaths worldwide, 1 57 million (80%) of which were in low-income countries. etween 1990 and 2020, these diseases are expected to increase by 120% for women and 137% for men in developing countries, compared with 30-60% in developed countries. By 2010, 60% of the world's heart disease is expected to occur in India. Furthermore, South Asians have a high prevalence of risk factors, and have ischaemic heart disease at an earlier age than do people in developed countries. Most data for patients with acute coronary syndromes are from several large registries There are fewer studies done in India 12-14 so little is known about the demographic pattern and predictors of severe disease in ACS, particular with NSTEMI.
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Sudarshan Palaparthi (2017) conducted an observational in Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) (n=100). High-risk clinical and electrocardiographic variables (e.g., central obesity, LV failure, ST elevation in aVR) vs. Absence of high-risk variables was evaluated on Significant left main coronary artery (LMCA) stenosis (≥50% diameter compromise).
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