Key result
In a prospective cohort of 50 patients undergoing open-heart surgery, acute renal failure occurred in 10% of patients and was associated with factors such as cardiopulmonary bypass time and lower hematocrit.
Why the study?
Acute kidney injury is a serious complication after cardiac surgery, prompting evaluation of pre- and peri-operative variables that predict the risk of developing ARF.
Observational (n=50)
No
This observational study highlights the incidence of acute renal failure after open-heart surgery and identifies pre- and peri-operative variables associated with its development.
Supports ARF monitoring in cardiac surgery; leaves open larger validation of bypass time and hematocrit associations.
Background: Acute kidney injury (AKI) is one of the most serious complications during the postoperative period of cardiac surgery. Multiple variables predict the ARF after cardiac surgery. Objective of this study was to evaluate the significance of pre and peri-operative variables which may help in predicting the chances of developing ARF after cardiac surgery.Methods: This study was an observational, prospective study conducted among patients who were scheduled to undergo open heart surgery under cardiopulmonary bypass.Results: In total, 50 patients who underwent open-heart surgery, ARF was seen in 5 patients, with the incidence rate of 10%. Acute renal failure was present in one patient with ejection fraction <35, 2 patients had ejection fraction between 35 to 50 and 2 patients with ejection fraction >50. It was seen in 4 patients with 1-2 hrs of cardiopulmonary bypass and in 1 patient with >2 hrs of cardiopulmonary bypass. ARF was also seen in 4 patients with hematocrit between 22-26% and in 1 patient with >26%.Conclusions: The study provided a clinical variable score that can predict ARF after open-heart surgery. The score enhances the accuracy of prediction by accounting for the effect of all major risk factors of ARF.
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Dhaulta et al. (2019) conducted an observational in Open heart surgery under cardiopulmonary bypass (n=50). Pre-operative and peri-operative risk factors vs. Patients without risk factors was evaluated on Acute renal failure (rise of >50% above baseline in serum creatinine on postoperative day 1 to 3). In a prospective cohort of 50 patients undergoing open-heart surgery, acute renal failure occurred in 10% of patients and was associated with factors such as cardiopulmonary bypass time and lower hematocrit.
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