Key result
Silencing both beta-arrestin1 and beta-arrestin2 markedly increased up-regulated transcripts in response to AT1a receptor activation, showing their role in dampening the transcriptional response.
Beta-arrestin1 and beta-arrestin2 dampen the transcriptional response to AT1a receptor activation by promoting receptor desensitization, despite beta-arrestin2's specific role in supporting G protein-independent ERK1/2 activation.
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Hypothesis-generating in AT1a animal models; leaves open beta-arrestin targeting for human cardiovascular therapies.
Lee et al. (2007) studied this question. Selective RNA interference of beta-arrestin1 and beta-arrestin2 was evaluated on AT1a receptor desensitization, ERK1/2 activation and transcription. Silencing both beta-arrestin1 and beta-arrestin2 markedly increased up-regulated transcripts in response to AT1a receptor activation, showing their role in dampening the transcriptional response.
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