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Background: Ratfish liver oil (RLO) with a high abundance of valuable fatty acids, alkylglycerols (AKGs) and their methoxy derivates, is an ancient traditional Scandinavian medicine used to enhance the immune response in immune-related diseases and cancer. AKGs, also known as 1-O-alkyl-sn-glycerols or alkyl-etherlipids, are naturally occurring glyceryl ethers that are abundant in the liver of certain elasmobranch fish species such as ratfish or rabbitfish (Chimaera monstrosa), spiny dogfish (Squalus acanthias) and Greenland shark (Somniosus microcephalus). Shark liver oil (SLO) or AKGs incorporated into pharmaceutical products have been shown to display several in vivo biological efficacies such as stimulation of the immune system and anti-tumor and anti-metastatic activities.
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Mallakin et al. (2018) studied this question.
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