Why the study?
Do vesicant, irritant, and nonvesicant anticancer drugs have different injuring effects on porcine aorta endothelial cells?
Do vesicant, irritant, and nonvesicant anticancer drugs have different injuring effects on porcine aorta endothelial cells?
The in vitro injuring effects of anticancer drugs on porcine aorta endothelial cells correlate with their clinical classification as vesicant, irritant, or nonvesicant, suggesting this model may be useful for studying drug-induced vascular disorders.
Correlates in vitro endothelial injury with vesicant classification in a porcine model; leaves open human translation and clinical relevance.
Anticancer drugs are classified as vesicant, irritant, and nonvesicant drugs on the basis of frequency of their vascular disorder. In this study, we compared the injuring effects of three typical anticancer drugs of each class on porcine aorta endothelial cells (PAECs). The concentration inducing 50% cell viability inhibition was lower in the order of vesicant, irritant, and nonvesicant drugs. These results suggest that injuring effects of anticancer drugs on PAECs may be relevant as an indicator of frequency of their vascular disorder, and that this experimental model may be useful for the study of vascular disorder.
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Yamada et al. (2011) studied this question.
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