Key result
Being a sibling of a patient with primary coxarthrosis was associated with a higher prevalence of presenting symptoms of the disease compared to matched controls (8% vs 3.8%; p<0.05).
Why the study?
Is the prevalence of primary coxarthrosis higher in siblings of affected patients compared to matched controls?
Case-Control
Is the prevalence of primary coxarthrosis higher in siblings of affected patients compared to matched controls?
The significantly higher prevalence of primary coxarthrosis in siblings of affected patients suggests a hereditary factor in its etiology.
Answers are grounded in this paper and cite their sources.
May warrant inquiring about family history in coxarthrosis; leaves open genetic versus shared-environment contributions.
The prevalence of primary coxarthrosis was investigated in 289 siblings of 184 patients treated by total hip replacement. Age and sex-matched persons from the city files of Malmö, Sweden, were selected as controls. The prevalence of presenting symptoms (initiating a hip roentgen examination) of primary coxarthrosis in the siblings was 8%, compared to 3.8% in the controls (p less than 0.05). The type and localization of primary coxarthrosis was evenly distributed between the two groups. Conversely, the prevalence of gonarthrosis did not differ between the two groups. The prevalence of primary coxarthrosis in the siblings suggests the influence of a hereditary factor in the etiology of primary coxarthrosis.
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Håkan Lindberg (1986) conducted a case-control in Primary coxarthrosis. Sibling of a patient with primary coxarthrosis vs. Age and sex-matched controls was evaluated on Prevalence of presenting symptoms of primary coxarthrosis (p=<0.05). Being a sibling of a patient with primary coxarthrosis was associated with a higher prevalence of presenting symptoms of the disease compared to matched controls (8% vs 3.8%; p<0.05).
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