Mimicking Metallophosphatases: Revealing a Role for an OH Group with No Libido We thank the Royal Society and Nuffield foundation for financial support, and the BBSRC for a studentship (M.F.).

An intramolecular OH group can become much more effective in promoting phosphate hydrolysis when combined with multiple interactions in a model for the metallophosphatase active site (see picture; tacn=1,4,7-triazacyclononane). Supporting information for this article is available on the WWW under http://www.angewandte.com or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.