PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 1, 2020Theranostics50 citationsOpen Access

Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death

IOItziar OtanoSpanish National Cancer Research CentreMÁMaite ÁlvarezBioCruces Health research InstituteLMLuna MinuteHospital Universitario La Paz

Key Points

Key points are not available for this paper at this time.

Abstract

: The use of TNF blocking agents reduces oxidative stress, hyperpolarization of mitochondria, and the generation of DNA damage in CD8 T celss undergoing activation. The fact that TNF mediates AICD in human tumor-reactive CD8 T cells suggests that the use of TNF-blocking agents can be exploited in immunotherapy strategies.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Otano et al. (2020) studied this question.

synapsesocial.com/papers/6a204ebb1d7d35d060d1eb2dhttps://doi.org/10.7150/thno.41646
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.1992 · 897 citations
  2. 2The Death Receptor Fas (CD95/APO-1) Mediates the Deletion of T Lymphocytes Undergoing Homeostatic Proliferation2005 · 45 citations
  3. 3Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells1991 · 178 citations
  4. 4Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α1989 · 658 citations
  5. 5Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation2018 · 90 citations