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The mRNA transfection efficacy of double pH-responsive lipo-xenopeptides is strongly dictated by the lipid tail length and the position of the ionizable nitrogen within the lipo amino fatty acid domain, which govern endosomal escape mechanisms and interfacial localization. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Modulating mRNA carrier efficacy through the molecular catwalk of ionizable nitrogens in lipidic domains

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