A formalism for sensitivity analysis of stochastic models describing fluctuation phenomena in chemically reacting systems is developed. The method is not restricted to chemical kinetics and can be used to analyze any model of a physical system whose state variables obey stochastic differential equations with white noise. Expressions for the sensitivity coefficients and densities are obtained. These expressions are suitable for direct evaluation by means of a stochastic simulation in a computer. The relationship between these quantities and the response functions studied in statistical mechanics is discussed.
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Dacol et al. (1984) studied this question.
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