A number of lymphoma lines were characterized for sensitivity to natural killer (NK) cells present in the spleen in young CBA mice and reactivity with antisera directed against certain C‐type virus‐determined proteins expressed on the cell surface. Since no correlation was found, it is likely that the target of the NK cell is neither the antigen(s) recognized serologically by mice nor the group‐specific antigenic determinants of the viral proteins. Various target and effector cell combinations with regard to H‐2 composition did not indicate that H‐2 homology is necessary for the NK effect.
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Becker et al. (1976) studied this question.
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