Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults

Figures

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  Figure 1. Significant networks in the chronic pain-connectivity moderation analysis of the R2R rsFC when testing the PAIN_GROUP × PSQI interaction. Connections are represented by lines. The PAIN_GROUP × PSQI interaction was negative in all connections. The network formed by all eleven connections survived the TFNBS for the S-SP ROI configuration. The network formed by the blue solid and red connections survived the TFNBS for the SP-SP ROI configuration. The network formed by the red connections survived the TFNBS for the SP-A ROI configuration. The network formed by the solid red lines survived the TFNBS (marginally: left-tailed) for the S-A ROI configuration. The individual connection represented by the thicker red line was significant for all ROI configurations (p < 0.05, FDR corrected). The nodes of these networks are ROIs of the Harvard-Oxford AAL atlas. To clarify their anatomical extent, cortical ROIs are shown projected onto a semi-inflated white matter surface and subcortical ROIs are represented in the medial view of this surface. Pu = putamen. Cau = caudate. SMA = juxtapositional lobule cortex. PreCG = precentral gyrus. PostCG = postcentral gyrus.

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  Figure 2. Scatter plot of the rsFC values of the eleven connections that survived the TFNBS in the R2R connectivity analyses (when testing the PAIN_GROUP × PSQI interaction with the S-S ROI configuration) versus PSQI. The values of functional connectivity were adjusted by removing the demeaned residuals explained by age and sex. Thus, for each group (i.e., no-pain and chronic pain) the adjusted fitted rsFC lie in a straight line that represents the slope of the rsFC-PSQI dependency within the group. The negative PAIN_GROUP × PSQI interaction is explained by a change in slope from positive to negative when switching from the no-pain to the chronic pain group. For each connection, the Cohen's f2 local effect size index is shown, that is, the proportion of variance explained by the PAIN_GROUP × PSQI interaction divided by the residual variance. All effects were medium (0.15 ≤ f2 < 0.35) or large (f2 ≥ 0.35) [65]. Pu = putamen. Cau = caudate. SMA = juxtapositional lobule cortex. PreCG = precentral gyrus. PostCG = postcentral gyrus. R = right. L = left.