Answers are grounded in this paper and cite their sources.
Adrenocorticotrophin (ACTH), given as long-acting Synacthen depot (Ciba-Geigy), at 1000 micrograms/day, in divided doses 12 hourly, is known to increase blood pressure in man. Fifty micrograms/day of short-acting Synacthen given intravenously produced a rise in blood pressure and may be a threshold dose. Twelve hourly intramuscular injections of short-acting Synacthen over the dose range 100-400 micrograms/day was not sufficient to raise blood pressure.
No takes yet. Share an insight, caveat, or question.
Whitworth et al. (1987) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: