Why the study?
Does single oral dose tocainide reduce premature ventricular contractions in patients with frequent PVCs?
Population
8 patients with frequent premature ventricular contractions (PVCs)
Comparison
Single oral doses of 2-amino-2'… vs Intravenous lidocaine (intra-patient comparison)
Design
Case_series
Follow-up
48 hours
Authors
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May support tocainide evaluation for PVC suppression; leaves open chronic efficacy and safety in controlled trials.
Does single oral dose tocainide reduce premature ventricular contractions in patients with frequent PVCs?
Oral tocainide is an effective antiarrhythmic agent that suppresses PVCs with a pharmacokinetic profile suitable for chronic therapy.
McDevitt et al. (1976) studied this question.
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