Digital Health and Artificial Intelligence for PTSD: Improving Treatment Delivery Through Personalization

Posttraumatic stress disorder (PTSD) is a condition characterized by symptom heterogeneity and persistent avoidance patterns. These characteristics hinder the identification of candidates for early intervention and identification of treatment recommendations appropriate for an individual person's needs. Moreover, treatment barriers (particularly in areas with enduring disaster or conflict) further limit the delivery of behavioral interventions to ameliorate PTSD symptoms. To overcome these limitations, digital health approaches offer innovative ways for treatment delivery that extend beyond imitating face-to-face modalities. We discuss how digital health technologies have been increasingly used to bridge clinical needs. Another advantage of digital delivery is the automatic gathering of clinical data. We discuss how these clinical information pipelines can be analyzed using artificial intelligence to enhance prediction of PTSD, monitoring, and ad hoc treatment interventions. [ Psychiatr Ann . 2021;51(1):21–26.]