Randomized trial analyzes odds ratio dependence on variables in retrospective studies, suggesting a refined approach.
Quantification of the dependence of the odds ratio on concomitant variables associated with each of several 2 X 2 tables, using a regression model proposed by Zelen [1971], is an important tool for retrospective studies in epidemiology, An "exact" analysis may be based on the conditional likelihood obtained by fixing all the marginal totals. A symptotically this approach is equivalent to use of an unconditional log-linear model. The method is used to reanalyze data reported by Kneale [1971] on the relationship between obstetric radiation and childhood cancer.
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N. E. Breslow (1976) studied this question.
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