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October 5, 2012Journal of Bioresource ManagementOpen Access

After 4 weeks of Ang II infusion, ACE2 KO mice showed severe myocardial dysfunction (EF 39% vs 50%, FS 27% vs 38%) and enhanced remodeling compared to WT mice, despite similar increases in mean arterial pressure.

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Why the study?

Does ACE2 deficiency exacerbate cardiac and vascular pathological responses to chronic Angiotensin II infusion in mice?

Population

Eight-week-old male ACE2 knockout (KO) and wild type (WT) mice

Comparison

Angiotensin II subcutaneous infusion via… vs Wild type mice receiving the same Ang II infusion

Design

Preclinical

Follow-up

4 weeks

Authors

MAMahmoud S. AlghamriUniversity of MichiganNWNathan M. WeirMaverick (United States)MAMark P. AnstadtLifeBridge Health

Discussion

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Member takes

Overview

Supports ACE2's protective role in Ang II-driven remodeling; hypothesis-generating and should not yet change clinical practice.

Structured PICO

Does ACE2 deficiency exacerbate cardiac and vascular pathological responses to chronic Angiotensin II infusion in mice?

P
Population
Eight-week-old male ACE2 knockout (KO) and wild type (WT) mice
I
Intervention
Angiotensin II (Ang II) subcutaneous infusion (1000 ng/kg per min) via mini-osmotic pumps for 4 weeks
C
Comparator
Wild type (WT) mice receiving the same Ang II infusion
O
Outcome
Cardiac and vascular pathological responses including blood pressure, cardiac function, cardiac/aortic structure, and vascular inflammationsurrogate

ACE2 deficiency exacerbates Angiotensin II-induced cardiac dysfunction and aortic remodeling in mice, highlighting a cardio- and vascular-protective role of ACE2.

Cite This Study

Alghamri et al. (2012) studied this question.

synapsesocial.com/papers/6a206d2bddea50bfc43d205bhttps://doi.org/10.1177/1074248412460124
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Also Consider

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