The effects of hypocapnia and dilutional anemia on cerebral metabolism and circulation were examined in 20 anesthetized dogs. In ten dogs, a reduction in Paco2 to 11 mm Hg did not alter the cerebral oxygen consumption rate (CMRo2), but with subsequent dilution of hemoglobin to 5 gm/100 ml of blood,
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Michenfelder et al. (1969) studied this question.