Human peripheral lymphocytes were cultured in the presence of low (4μM) and high (100, 150 (μM) concenrations of zinc. Lymphocytes stimulated with phytohaemagglutinin (PHA) or tuberculin (PPD) synthesized metallothionein only in the presence of high concentrations of Zinc ions. Presence of a high zinc ion concentration alone did not stimulate the synthesis of DNA or of rnetallotnionein.
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Alexander et al. (1982) studied this question.
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