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September 1, 1976Clinical Science

Low-Density Lipoproteins in Patients Homozygous for Familial Hyperbetalipoproteinaemia

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Population

2 patients homozygous for familial hyperbetalipoproteinaemia

Design

Case_series

Authors

GMG.L. MillsUniversity of NottinghamCTC.E. TaylaurUniversity College LondonMCM. John ChapmanSorbonne Université

Discussion

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Implication

Does not inform clinical management; leaves open the functional role of this anomalous LDL.

Key Points

  • To analyze the low-density lipoproteins from patients homozygous for familial hyperbetalipoproteinaemia and characterize their composition.
  • Performed chemical and physicochemical analysis of LDL from two patients.
  • Examined proportions of triglycerides, cholesterol, carbohydrates, phospholipids, and fatty acids in LDL samples.
  • Measured molecular weight and diffusion constant of the abnormal LDL.
  • An anomalous lipoprotein had low triglyceride and high cholesterol, making up 85% of LDL in one patient.
  • The protein composition of the abnormal LDL was similar to that of healthy subjects.
  • Molecular weight and diffusion properties of the abnormal lipoprotein were comparable to normal LDL values.

Structured PICO

P
Population
2 patients homozygous for familial hyperbetalipoproteinaemia
C
Comparator
Low-density lipoproteins (LDL) from healthy subjects
O
Outcome
Chemical and physicochemical properties of low-density lipoproteins (LDL), including triglyceride and cholesterol proportions, amino acid composition, molecular weight, and diffusion constantsurrogate

Patients homozygous for familial hyperbetalipoproteinaemia possess an anomalous LDL particle characterized by altered triglyceride and cholesterol proportions but otherwise normal structural properties.

Cite This Study

Mills et al. (1976) studied this question.

synapsesocial.com/papers/6a2076c204d2adee4bf48caehttps://doi.org/10.1042/cs0510221
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Characterization of a Discrete Series of Low Density Lipoproteins in the Disease, Hyper-pre-β-lipoproteinemia1971 · 117 citations
  2. 2THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM1955 · 8,814 citations
  3. 3The Molecular Weights and Dimensions of Some Human Serum Lipoproteins1956 · 47 citations