IMMUNOLOGIC EVIDENCE FOR MONKEY AND HUMAN PROLACTIN (MPr and HPr)

H. Guyda; P. Hwang; Henry G. Friesen

doi:10.1210/jcem-32-1-120

January 1, 1971The Journal of Clinical Endocrinology & Metabolism

IMMUNOLOGIC EVIDENCE FOR MONKEY AND HUMAN PROLACTIN (MPr and HPr)

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Key Points

To investigate the immunologic characteristics of monkey and human prolactin, particularly their cross-reactivity with ovine prolactin.
Developed a radioimmunoassay to differentiate between human prolactin (HPr) and monkey prolactin (MPr) from human growth hormone (HGH) and monkey growth hormone (MGH).
Tested the cross-reactivity of antibodies specific to MPr with ovine prolactin (OPr).
Antibodies to monkey prolactin exhibited cross-reactivity with ovine prolactin.
The radioimmunoassay effectively distinguished HPr and MPr from HGH and MGH.

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Implication

Research demonstrates antibody cross-reactivity and assay development for distinguishing human and monkey prolactin.

Abstract

Antibodies to MPr cross react with ovine prolactin (OPr). A radioimmunoassay for prolactin was developed which can distinguish HPr and MPr from human and monkey growth hormone (HGH and MGH).

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Guyda et al. (1971) studied this question.

synapsesocial.com/papers/6a2076dea40bcbc79e09985c https://doi.org/10.1210/jcem-32-1-120

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IMMUNOLOGIC EVIDENCE FOR MONKEY AND HUMAN PROLACTIN (MPr and HPr)

Key Points

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Implication

Abstract

Discussion

Cite This Study

IMMUNOLOGIC EVIDENCE FOR MONKEY AND HUMAN PROLACTIN (MPr and HPr)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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