Key result
A genetic or acquired defect of nitric oxide synthesis may trigger the metabolic, vascular, and sympathetic abnormalities characteristic of insulin-resistant states.
Population
Healthy people and insulin-resistant subjects
Design
Review
Authors
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May implicate nitric oxide defects in insulin resistance; leaves open whether NO-targeted therapies alter cardiometabolic risk.
A defect in nitric oxide synthesis may be a central trigger for the metabolic, vascular, and sympathetic abnormalities seen in insulin resistance, predisposing to cardiovascular disease.
Sartori et al. (1999) conducted a review in Insulin resistance and cardiovascular morbidity. Insulin was evaluated. A genetic or acquired defect of nitric oxide synthesis may trigger the metabolic, vascular, and sympathetic abnormalities characteristic of insulin-resistant states.
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