Key result
An adapted Holter analysis system detected significant circadian variations in high-frequency RR variations, but no changes preceding periods of ST segment depression were observed.
Holter-based heart rate spectrum analysis reveals significant circadian variations in high-frequency RR intervals, though mid-frequency ranges are unreliable for measuring sympathetic tone.
Hypothesis-generating for circadian HF RR variations; does not support HRV-based prediction of ST depression.
This investigation was undertaken to develop and test methods for tracking the state of the autonomic nervous system. Different regions of the heart rate spectrum are known to reflect changes in tone of the two branches of the autonomic nervous system. Because these changes have been shown to affect prognosis of patients with coronary heart disease, a commercial Holter analysis system was adapted to track them. The mid-frequency range was shown to be too corrupted by vagal activity to be useful as a measure of sympathetic tone. Significant circadian variations in high-frequency RR variations were observed but changes preceding periods of ST segment depression were not.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Feldman et al. (2002) studied Coronary heart disease. Adapted Holter analysis system was evaluated on Circadian variations in high-frequency RR variations and changes preceding ST segment depression. An adapted Holter analysis system detected significant circadian variations in high-frequency RR variations, but no changes preceding periods of ST segment depression were observed.
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