August 1, 1997Pain
Right-hemisphere preponderance of responses to painful CO2 stimulation of the human nasal mucosa
Population
9 healthy adults
Comparison
Painful CO2 pulses delivered to the left or… vs Air puffs delivered to the nasal mucosa, lip…
Design
Other
Authors
Discussion
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Implication
Right-hemisphere dominance may shape trigeminal pain affect; leaves open targeted neuromodulation hypotheses.
Structured PICO
P
Population
9 healthy adults
I
Intervention
Painful CO2 pulses (duration 200 ms, concentration 65-90%) delivered to the left or right nostril
C
Comparator
Air puffs delivered to the nasal mucosa, lip, and forehead
O
Outcome
Whole-scalp cerebral magnetic fields (responses 280-400 ms after stimulus onset)surrogate
Painful CO2 stimulation of the nasal mucosa elicits right-hemisphere dominant cerebral magnetic fields, suggesting right hemisphere involvement in emotional/motivational aspects of trigeminal pain.
Cite This Study
Hari et al. (1997) studied this question.