Key result
A previously healthy young male with unprovoked deep vein thrombosis and acute ischemic stroke was found to have nonbacterial thrombotic endocarditis associated with advanced cholangiocarcinoma.
Why the study?
Nonbacterial thrombotic endocarditis is typically seen in advanced malignancy, but its association with cholangiocarcinoma is rarely reported.
Case Report (n=1)
Highlights a rare case of nonbacterial thrombotic endocarditis presenting as acute ischemic stroke as the initial manifestation of advanced cholangiocarcinoma in a young patient.
Answers are grounded in this paper and cite their sources.
Prompts malignancy workup in young patients with unprovoked DVT and stroke; leaves broader NBTE screening implications open.
Nonbacterial thrombotic endocarditis, a form of noninfectious thrombotic endocarditis, is mainly characterized by deposition of sterile platelet thrombi on heart valves. Usually, it is observed in advanced malignancy. Herein, we report a case of a previously healthy male with recent unprovoked deep vein thrombosis presented with acute ischemic stroke. The echocardiogram revealed aortic and mitral valve masses. Eventually, he was discovered to have advanced cholangiocarcinoma. The present case, apart from being the youngest reported case, is among the few reported cases which manifest the association between cholangiocarcinoma and nonbacterial thrombotic endocarditis.
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Al-Ghamdi et al. (2020) conducted a case report in Nonbacterial thrombotic endocarditis and advanced cholangiocarcinoma (n=1). Advanced cholangiocarcinoma was evaluated. A previously healthy young male with unprovoked deep vein thrombosis and acute ischemic stroke was found to have nonbacterial thrombotic endocarditis associated with advanced cholangiocarcinoma.
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