Key result
Non-increased plasmin α2-plasmin inhibitor complex with increased thrombin-antithrombin complex was an independent risk factor for VTE development (OR 9.4).
Why the study?
Does the combination of non-increased PIC and increased TAT predict VTE development in hospitalized Japanese patients receiving chemotherapy for malignancies?
Observational (n=97)
No
Does the combination of non-increased PIC and increased TAT predict VTE development in hospitalized Japanese patients receiving chemotherapy for malignancies?
Odds Ratio: 9.4 (95% CI 1.7–51.9)
Absolute Event Rate: 28% vs 3%
p-value: p=0.011
The prevalence and incidence of VTE are high in hospitalized Japanese patients receiving chemotherapy, and the combination of non-increased PIC with increased TAT may serve as an independent predictor for VTE development.
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May flag high-risk chemotherapy patients for VTE monitoring; hypothesis-generating and requires prospective validation before guiding practice.
Kitayama et al. (2017) conducted an observational in Malignancies (n=97). Non-increased PIC with increased TAT vs. Without non-increased PIC and increased TAT was evaluated on Objectively confirmed newly developed VTE (OR 9.4, 95% CI 1.7-51.9, p=0.011). Non-increased plasmin α2-plasmin inhibitor complex with increased thrombin-antithrombin complex was an independent risk factor for VTE development (OR 9.4).
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