Key result
Countertherapeutic anticholinergic effects were most evident in good outcome schizophreniform cases, particularly catatonics, while paranoids showed the least effects and no relation to prognosis.
Why the study?
Do anticholinergic anti-parkinsonism drugs have countertherapeutic effects that correlate with nosological and prognostic distinctions in schizophrenia?
Observational
Do anticholinergic anti-parkinsonism drugs have countertherapeutic effects that correlate with nosological and prognostic distinctions in schizophrenia?
The countertherapeutic effects of anticholinergic drugs in schizophrenia vary by diagnostic subtype and correlate with prognosis, being most evident in catatonic patients.
May warrant subtype consideration with anticholinergics in schizophrenia; leaves open causality and needs prospective trials.
In studying the relationships between anticholinergic-neuroleptic interactions and the nosological and prognostic distinctions in schizophrenia, we have shown that these distinctions have clinicopathological meaning. The countertherapeutic anticholinergic effects seemed to be particularly evident in the good outcome, schizophreniform cases and differentiated between the three diagnostic subtypes. Such effects were most conspicuous in the catatonics who also had the most favorable prognosis, while the paranoids differed from others in not only showing the least anticholinergic effects but also in not conforming to the relationship between these effects and prognosis. The findings are briefly considered in relation to those with wheat gluten which has also been shown to be a countertherapeutic factor in schizophrenia in another study.
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Singh et al. (2008) conducted an observational in Schizophrenia. Anticholinergic anti-parkinsonism drugs and neuroleptics was evaluated on Countertherapeutic anticholinergic effects and prognosis. Countertherapeutic anticholinergic effects were most evident in good outcome schizophreniform cases, particularly catatonics, while paranoids showed the least effects and no relation to prognosis.
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