What is the clinical evidence from this study?

Study design: Other. Population: Peripheral arterial insufficiency (femoral artery occlusion model) (n=44). Intervention: One-time acute heat treatment vs. Pre-heat control session. Primary outcome: Mean arterial pressure (MAP) response to static muscle contraction (p=<0.05).

August 6, 2020Frontiers in PhysiologyOpen Access

One-Time Acute Heat Treatment Is Effective for Attenuation of the Exaggerated Exercise Pressor Reflex in Rats With Femoral Artery Occlusion

Q: What are the key findings of this study?

One-time acute heat treatment significantly attenuated the amplified mean arterial pressure response to static muscle contraction in rats with femoral artery occlusion (19 ± 8 mmHg vs 28 ± 2 mmHg, p < 0.05).

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Why the study?

Does one-time acute heat treatment reduce the exaggerated exercise pressor reflex in a rat model of peripheral arterial insufficiency?

Population

Male Sprague-Dawley rats with peripheral arterial insufficiency induced by right femoral artery occlusion…

Comparison

One-time acute heat treatment applied locally to… vs Pre-heat control session and sham-operated…

Design

Preclinical

Follow-up

Acute

Key result

One-time acute heat treatment significantly attenuated the amplified mean arterial pressure response to static muscle contraction in rats with femoral artery occlusion (19 ± 8 mmHg vs 28 ± 2 mmHg, p < 0.05).

Authors

LQLu Qin JLJianhua Li

Discussion

Member takes

Overview

Hypothesis-generating for heat therapy in peripheral arterial insufficiency; should not yet change clinical practice.

Structured PICO

Does one-time acute heat treatment reduce the exaggerated exercise pressor reflex in a rat model of peripheral arterial insufficiency?

Population

44 male Sprague-Dawley rats with or without simulated peripheral artery disease (femoral artery occlusion) evaluated for blood pressure responses to muscle contraction before and after acute heat treatment.

Intervention

One-time acute heat treatment (HT) applied locally to the hindlimb via heating pad, increasing muscle temperature by ~1.5 °C and maintained for 5 min.

Comparator

Pre-heat control session and sham-operated control rats.

Outcome

Blood pressure (BP) response (mean arterial pressure) to static muscle contraction and muscle tendon stretch.surrogate

Main Result

Absolute Event Rate: 19% vs 28%

p-value: p=<0.05

One-time acute heat treatment selectively attenuates the amplified pressor response to muscle contraction in a rat model of peripheral arterial insufficiency, likely by reducing metabolites stimulating muscle afferent nerves.

Limitations

Static exercise protocols are not surrogates for dynamic exercise in humans or treadmill exercise in rats.
Only male rats were used, so the effects of acute heat treatment on the exercise pressor reflex in females remain unknown.
Experiments were conducted 3 days following femoral artery occlusion, which may not mimic the stabilized human condition.
The specific metabolites responsible for the attenuation of the blood pressure response to static contraction following acute heat treatment were not definitively identified.
A rat model with femoral artery occlusion does not fully exhibit all the clinical symptoms of PAD

Cite This Study

Qin et al. (2020) studied Peripheral arterial insufficiency (femoral artery occlusion model) (n=44). One-time acute heat treatment vs. Pre-heat control session was evaluated on Mean arterial pressure (MAP) response to static muscle contraction (p=<0.05). One-time acute heat treatment significantly attenuated the amplified mean arterial pressure response to static muscle contraction in rats with femoral artery occlusion (19 ± 8 mmHg vs 28 ± 2 mmHg, p < 0.05).

synapsesocial.com/papers/6a207ed9cd682a52c6f89541 https://doi.org/10.3389/fphys.2020.00942

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August 6, 2020Frontiers in PhysiologyOpen Access

One-Time Acute Heat Treatment Is Effective for Attenuation of the Exaggerated Exercise Pressor Reflex in Rats With Femoral Artery Occlusion

View Full Paper

Ask AI

Bookmark

Why the study?

Does one-time acute heat treatment reduce the exaggerated exercise pressor reflex in a rat model of peripheral arterial insufficiency?

Population

Male Sprague-Dawley rats with peripheral arterial insufficiency induced by right femoral artery occlusion…

Comparison

One-time acute heat treatment applied locally to… vs Pre-heat control session and sham-operated…

Design

Preclinical

Follow-up

Acute

Key result

Authors

LQLu Qin JLJianhua Li

Discussion

Member takes

Overview

Hypothesis-generating for heat therapy in peripheral arterial insufficiency; should not yet change clinical practice.

Structured PICO

Does one-time acute heat treatment reduce the exaggerated exercise pressor reflex in a rat model of peripheral arterial insufficiency?

Population

Intervention

One-time acute heat treatment (HT) applied locally to the hindlimb via heating pad, increasing muscle temperature by ~1.5 °C and maintained for 5 min.

Comparator

Pre-heat control session and sham-operated control rats.

Outcome

Blood pressure (BP) response (mean arterial pressure) to static muscle contraction and muscle tendon stretch.surrogate

Main Result

Absolute Event Rate: 19% vs 28%

p-value: p=<0.05

Limitations

Static exercise protocols are not surrogates for dynamic exercise in humans or treadmill exercise in rats.
Only male rats were used, so the effects of acute heat treatment on the exercise pressor reflex in females remain unknown.
Experiments were conducted 3 days following femoral artery occlusion, which may not mimic the stabilized human condition.
The specific metabolites responsible for the attenuation of the blood pressure response to static contraction following acute heat treatment were not definitively identified.
A rat model with femoral artery occlusion does not fully exhibit all the clinical symptoms of PAD

Cite This Study

synapsesocial.com/papers/6a207ed9cd682a52c6f89541 https://doi.org/10.3389/fphys.2020.00942

Also Consider

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