Key result
Lower overall physical health scores on the SF-36 were associated with coronary artery disease risk factors and significantly predicted 5-year all-cause mortality in high-risk cardiac patients.
Why the study?
Are SF-36 domain scores associated with CAD risk factors and 5-year all-cause mortality in high-risk cardiac patients?
Cohort (n=1,785)
Are SF-36 domain scores associated with CAD risk factors and 5-year all-cause mortality in high-risk cardiac patients?
Self-reported physical health on the SF-36 is a significant predictor of 5-year mortality and correlates with CAD risk factors in high-risk cardiac patients.
May aid mortality risk stratification in high-risk cardiac patients; hypothesis-generating and requires prospective validation before practice change.
This study examined the relationships among health-related quality of life and risk factors of coronary artery disease (CAD) and all-cause mortality in high-risk cardiac patients seen in a cardiology prevention clinic. At baseline, 1785 patients (age, 53.4+/-13.4 years; 58.8% men) had a medical history, physical examination, and laboratory tests. They completed the Medical Outcomes Study Short Form-36-Item Health Survey (SF-36). Analyses were conducted on associations of 2 SF-36 domain scores (overall physical health [OPH] and overall mental health [OMH]) with CAD biomarkers and all-cause mortality. Lower OPH scores were associated with CAD risk factors including smoking; history of hypertension, diabetes, and peripheral artery disease; the metabolic syndrome; and other novel CAD biomarkers. Lower OMH scores showed similar but weaker associations with CAD risk factors. OPH significantly predicted 5-year mortality in multivariable survival analysis. SF-36, especially OPH, was associated with many risk factors of CAD and significantly predicted mortality.
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Zhang et al. (2009) conducted a cohort in High-risk cardiac patients (n=1,785). SF-36 domain scores (overall physical health and overall mental health) was evaluated on Coronary artery disease risk factors and all-cause mortality. Lower overall physical health scores on the SF-36 were associated with coronary artery disease risk factors and significantly predicted 5-year all-cause mortality in high-risk cardiac patients.
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