Key result
Bariatric surgery reduced the prevalence of dyspnea from 90% to 59%, and this improvement was significantly associated with an increase in Expiratory Reserve Volume.
Why the study?
Does bariatric surgery improve dyspnea and is this improvement associated with changes in Expiratory Reserve Volume in patients with obesity?
Cohort (n=45)
No
Does bariatric surgery improve dyspnea and is this improvement associated with changes in Expiratory Reserve Volume in patients with obesity?
Bariatric surgery significantly improves dyspnea in patients with obesity, an effect that is independently associated with an increase in Expiratory Reserve Volume.
Bariatric surgery was associated with reduced dyspnea in obesity; hypothesis-generating ERV link requires randomized confirmation.
OBJECTIVES: To assess the effects of bariatric surgery in patients with obesity on dyspnea and to analyze the relationships between improvement of dyspnea after bariatric surgery and changes in pulmonary function, especially Expiratory Reserve Volume (ERV) which is the lung volume abnormality most frequently associated with obesity. METHODS: Forty-five patients (5 males/40 females, mean Body Mass Index = 46.2 ± 6.8 kg/m2) were evaluated before and 6 to 12 months after bariatric surgery. Dyspnea was assessed by the modified Medical Research Council (mMRC) scale. Pulmonary function tests, arterial blood gases and six-minute walk test were performed. Laboratory parameters including C-Reactive Protein (CRP) were analyzed. RESULTS: Ninety percent of patients were dyspneic before surgery (mMRC scale ≥ 1) versus 59% after surgery (p<0.001). Mean mMRC score improved after bariatric surgery (1.5 ± 0.9 vs 0.7 ± 0.7, p<0.0001). Among patients with dyspnea before surgery (n = 38), a more marked increase in ERV after surgery was observed in patients with improvement of dyspnea compared to patients with no improvement of dyspnea (+0.17 ± 0.32 L vs +0.49 ± 0.35 L, p = 0.01). Multivariate analysis including age, variation of BMI, variation of CRP, variation of Total Lung Capacity and variation of ERV demonstraded that ERV was the only variable associated with improvement of the mMRc score after bariatric surgery (p = 0.04). CONCLUSION: Weight loss associated with bariatric surgery improves dyspnea in daily living. This improvement could be partly related to increased ERV.
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Boissière et al. (2017) conducted a cohort in Obesity with dyspnea (n=45). Bariatric surgery vs. Baseline (before surgery) was evaluated on Prevalence of dyspnea in daily living (mMRC scale ≥ 1) (p=<0.001). Bariatric surgery reduced the prevalence of dyspnea from 90% to 59%, and this improvement was significantly associated with an increase in Expiratory Reserve Volume.
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