Use of patient portals to support recruitment into clinical trials and health research studies: results from studies using MyChart at one academic institution

Electronic health records (EHRs) are often used for recruitment into research studies, as they efficiently facilitate targeted outreach. While studies increasingly are reaching out to potential participants through the EHR patient portal, there is little available information about which approaches are most effective. We surveyed all investigators at one academic medical center who had used the Epic MyChart patient portal for recruitment. We found that messages were typically adapted for a large group, but not tailored further for individual subgroups. The vast majority of studies sent a message only once. Recruitment costs were modest, averaging 431/study. The results show some promise for recruiting through the patient portal but also identified ways in which messages could be optimized.